Magnetic Nanoparticles in Human Health and Medicine – Current Medical Applications and Alternative Therapy of Cancer

Costica Caizer, PhD, is Associate Professor, Department of Physics, West University of Timisoara, Romania. Professor Caizer is a specialist in magnetism, nanomagnetism, and magnetic nanoparticles and their applications in magnetic hyperthermia for alternative cancer therapy. Mahendra Rai, PhD, is Professor, Department of Biotechnology, Sant Gadge Baba Amravati University, India. Professor Rai has edited more than 60 books and published over 400 research papers and reviews in international peer-reviewed journals. List of Contributors 1. An introduction to magnetic nanoparticles: from bulk to nanoscale magnetism and their applicative potential in human health and medicine Costica Caizer1*, Shital Bonde2, and Mahendra Rai2 1West University of Timisoara, Department of Physics, Bd. V. Parvan no. 4, 300223 – Timisoara, Romania 2UGC-Basic Science Research Faculty, Department of Biotechnology, SGB Amravati University, Amravati – 444 602, Maharashtra, India Part I. Current Biomedical Applications of Magnetic Nanoparticles 2. Magnetic nanoparticles in nanomedicine Gabriela Fabiola Stiufiuc1, Cristian Iacovita2, Valentin Toma3, Rares Ionu Stiufiuc2,3, Romulus Tetean1* and Constantin Mihai Lucaciu3 1 Faculty of Physics, “Babes-Bolyai” University, Cluj-Napoca, Romania 2MedFuture Research Center for Advanced Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 3Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 3. Clustering of magnetic nanoparticles for nanomedicine Giacomo Mandriota1, Riccardo Di Corato2* 1Istituto Italiano di Tecnologia, via Morego 30, 16163 Genoa, Italy 2CNR-IMM, Institute for Microelectronics and Microsystems, Via Monteroni – Campus Ecotekne, 73100 Lecce, Italy 4. Multifunctional bioactive magnetic scaffolds with tailored features for bone tissue engineering Teresa Russo1*, Roberto De Santis1, Valentina Peluso2, Antonio Gloria1 1 Institute of Polymers, Composites and Biomaterials (IPCB) – National Research Council of Italy 2 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples “Federico II”, Naples, Italy 5. Magnetic nanoparticles in the development of polymer scaffolds for medical applications Larissa Stieven Montagna, Ana Paula da Silva, Amanda de Sousa Martinez de Freitas, Ana Paula Lemes* Polymers and Biopolymers Technology Laboratory, (TecPBio), Department of Science and Technology, Federal University of Sao Paulo, So Jos dos Campos, SP, Brazil 6. Magnetic polymer colloids for ultrasensitive molecular imaging Sundas Riaz1, Sumera Khizar1, Nasir M. Ahmad1* Gul Shahnaz2 Noureddine Lebaz3 Abdelhamid Elaissari3* 1Polymer Research Lab, School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), H-12 Sector, Islamabad-44000, Pakistan 2Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad-45320, Pakistan 3Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEPP UMR-5007, 43 boulevard du 11 novembre 1918, F-69100, Villeurbanne, France 7. Iron oxide nanoparticles in anticancer drug delivery and imaging diagnostics Miroslava Nedyalkova1*, Boyan Todorov1, Haruna L. Barazorda-Ccahuanac2, Sergio Madurga3 1 Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, Sofia, Bulgaria 2 Centro de Investigacin en Ingeniera Molecular-CIIM, Universidad Catlica de Santa Mara, Arequipa, Per 3 Faculty of Chemistry, Barcelona University, Barcelona, Spain 8. Functional addressable magnetic domains and their potential applications in theranostics Sihomara Patricia Garca-Zepeda1, Jaime Santoyo-Salazar2* 1Toxicology Department, Centro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional, CINVESTAV-IPN, 07360 Mexico City, Mexico 2*Physics Department, Centro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional, CINVESTAV-IPN, 07360 Mexico City, Mexico 9. Nuclear/MR magnetic nanoparticle-based probes for multimodal biomedical imaging Eirini Fragogeorgi1,2*, Sophia Sarpaki2, Maritina Rouchota2, Panagiotis Papadimitroulas2 and Maria Georgiou2 1Institute of Nuclear & Radiological Sciences, Technology, Energy & Safety (INRASTES), NCSR ”Demokritos”, Ag. Paraskevi-Athens, Greece 2Bioemission Technology Solutions (BIOEMTECH), Lefkippos Attica Technology Park, NCSR “Demokritos”, Ag. Paraskevi-Athens, Greece Part II. Magnetic Nanoparticles in Alternative Cancer Therapy 10. Magnetic nanoparticles hyperthermia: the past, the present and the future Dawn Blazer, Yohannes Getahun, Ahmed A. El-Gendy*, University of Texas El Paso, Department of Physics, El Paso, TX 79968, USA 11. Drug delivery and magnetic hyperthermia based on surface engineering of magnetic nanoparticles Guilherme N. Lucena1,2, Caio C. dos Santos1, Gabriel C. Pinto1 Bruno E. Amanta1, Rodolfo D. Piazza1, Miguel Jafelicci Jr1, Rodrigo Fernando C. Marques1,2,3* Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, So Paulo State University (UNESP), BRAZIL 12. Improving magneto-thermal energy conversion efficiency of magnetic fluids through external DC magnetic field induced orientational ordering B. B. Lahiri, Surojit Ranoo, Fouzia Khan, John Philip Smart Materials Section, Corrosion Science and Techonlogy Division, Materials Characterization Group, Metallurgy amd Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamil Nadu, PIN 603102, India 13. Classical Magnetoliposomes vs Current Magnetociclodextrins with Ferrimagnetic Nanoparticle for High Efficiency and Low Toxicity in Alternative Therapy of Cancer by Magnetic/ Superparamagnetic Hyperthermia Costica Caizer1*, Cristina Dehelean2, Codruta Soica2 1*West University of Timisoara, Faculty of Physics, Bv. V. Parvan no. 4, 300223 – Timisoara, Romania; e-mail: costica.caizer@e-uvt.ro 2″Victor Babes” University of Medicine and Pharmacy, Faculty of Pharmacy, P-zza. E. Murgu no. 2, 300041 – Timisoara, Romania 2″Victor Babes” University of Medicine and Pharmacy, Faculty of Pharmacy, P-zza. E. Murgu no. 2, 300041 – Timisoara, Romania 14. Efficiency of energy dissipation in nanomagnets: a theoretical study of AC susceptibility F. Vernay, J.-L. Djardin, H. Kachkachi* Universit de Perpignan via Domitia, Lab. PROMES CNRS UPR8521, Rambla de la Thermodynamique, Tecnosud, 66100 Perpignan, France 15. Magnetic Nanoparticle Relaxation in Biomedical Application: Focus on Simulating Nanoparticle Heating Ulrich M. Engelmann1,2*, Carolyn Shasha3, and Ioana Slabu2 1Department of MedicalEngineering and Applied Mathematics, FH Aachen University of Applied Sciences, Aachen, Germany 2Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University,Aachen, Germany 3Department of Physics, University of Washington, Seattle, WA 98195, USA 16. Magnetic Nanoparticles in Alternative Tumors Therapy: Biocompatibility, Toxicity and Safety Compared with Classical Methods Costica Caizer1 and Mahendra Rai2 1West University of Timisoara, Department of Physics, Bd. V. Parvan no. 4, 300223 – Timisoara, Romania 2UGC-Basic Science Research Faculty, Department of Biotechnology, SGB Amravati University, Amravati – 444 602, Maharashtra, India 17. The size, shape and composition design of iron oxide nanoparticles to combine MRI, magnetic hyperthermia and photothermia Barbara Freis1, Geoffrey Cotin1, Francis Perton1 Damien Mertz1, Sylvie Begin-Colin1* Sophie Laurent2,3 Sebastien Boutry2,3 1Universit de Strasbourg, CNRS, Institut de Physique et Chimie des Matriaux de Strasbourg, UMR 7504, F-67034 , Strasbourg, France 2Universit de Mons, General, Organic and Biomedical Chemistry Unit, NMR and Molecular Imag-ing Laboratory, 7000 , Mons, Belgium 3. Center for Microscopy and Molecular imaging (CMMI), Gosselies, Belgium 18. Magnetic/Superparamagnetic hyperthermia in clinical trials for non-invasive alternative cancer therapy Costica Caizer West University of Timisoara, Department of Physics, Bv. V. Parvan no. 4, 300223 – Timisoara, Romania Index